FZD10 antibody (PE-Cy7)

Catalog No. ABIN1713248

The Rabbit Polyclonal anti-FZD10 antibody has been validated for WB. It is suitable to detect FZD10 in samples from Human, Mouse, Rat, Pig, Cow, Dog and Chicken.

Quick Overview for FZD10 antibody (PE-Cy7) (ABIN1713248)

Target: FZD10 (Frizzled Family Receptor 10 (FZD10))

Reactivity: Human, Mouse, Rat, Pig, Cow, Dog, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FZD10 antibody is conjugated to PE-Cy7

Application: Western Blotting (WB)

Product Details anti-FZD10 Antibody (PE-Cy7)

Specificity: Due to the similarity of this protein to Frizzled 9, there is a chance that this antibody will react with this protein based on homology.

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Frizzled 10/CD350

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FZD10

Target: FZD10 (Frizzled Family Receptor 10 (FZD10))

Alternative Name: Frizzled 10/CD350

Background:

Synonyms: Fz10, FzE7, CD350, FZ-10, hFz10, Frizzled-10, FZD10

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Gene ID: 11211

UniProt: Q9ULW2

Pathways: WNT Signaling